Published: Thu, August 24, 2017
Medical | By Carla Vaughn

Clear Link Between Heavy Vitamin B Intake And Lung Cancer

Clear Link Between Heavy Vitamin B Intake And Lung Cancer

One study will examine associations in post-menopausal women in order to confirm the current finding of no elevated risk in women.

A new study suggests the body's stem cells can soak up unusually high levels of vitamin-C.

Researchers said there was no increased risk of lung cancer in women who took high doses of vitamin B.

Male smokers who consumed the highest levels of vitamin B6 more than tripled their lung cancer risk over six years. What was less surprising was that increased risks of lung cancer were found in current cigarette smokers.

Said Ohio State's Theodore Brasky, PhD: "This sets all of these other influencing factors as equal, so we are left with a less confounded effect of long-term B6 and B12 super-supplementation...."

When researchers evaluated 10-year average supplement doses, results revealed a near-doubling of lung cancer risk among men in the highest categories of vitamin B6 supplementation ( 20 mg per day, HR = 1.82; 95% CI, 1.25-2.65) and vitamin B12 supplementation ( 55 µg per day, HR = 1.98; 95% CI, 1.32-2.97) compared with nonusers.

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Taking vitamins B12 or B6 over an extended period has been found to dramatically increase the odds of getting lung cancer in men, a new study finds.

Researchers crunched data from 77,000-plus patients participants in a long-term, prospective observational study called the VITamins And Lifestyle (VITAL) cohort study.

Although the conclusions are concerning, Dr. Brasky is quick to explain, "These are doses that can only be obtained from taking high-dose B vitamin supplements, and these supplements are many times the U.S. Recommended Dietary Allowance". The team report their findings in Journal of Clinical Oncology.

All participants were aged between 50 and 76 were recruited in the state of Washington between the years 2000 and 2002. Among them, long term high-dose supplementation was associated with 3-4 fold increases in lung cancer risk.

"But if you look at these supplement bottles, they're being sold in pill form at up to 5,000 micrograms per dose, which is much, much higher than the daily recommended amount", Brasky said. He responded, "I don't think we were surprised by the direction of the association both because of the context of prior literature as well as the general idea that there are often U-shaped associations between nutrition and disease". These supplements have been broadly thought to reduce cancer risk. Notably, smoking seemed to increase the chances of developing the disease significantly more when coupled with vitamin B supplements. "This is certainly a concern worthy of further evaluation". "Combustible tobacco smoke is the No. 1 most important factor, not just only in lung cancer but in many cancers".

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